San Luis is a city in Yuma County, Arizona, United States. The population was 25,505 at the 2010 census. It is part of the Yuma Metropolitan Statistical Area. San Luis, located in the southwest corner of the state directly adjacent to Mexico's Federal Highway 2, was the second fastest-growing city or town in Arizona from 1990 to 2000. According to 2014 Census Bureau estimates, the population of the city is 31,091.